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. 2015 Dec 4;47(12):e197. doi: 10.1038/emm.2015.88

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Copyright © 2015 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Co-occurrence of synovial inflammation and cartilage erosion in experimental RA and OA mouse models. (a) Safranin-O/hematoxylin staining and enlarged images of synovium and cartilage in knee joints of DBA/1 J mice immunized with type II collagen (CIA) or not immunized (NI) (n=15 per group). (b) Representative images of synovium and cartilage in knee joints from C57BL/6 mice after sham surgery or destabilization of the medial meniscus (DMM) (n=15 per group). (c) Scoring of synovial inflammation (synovitis) or cartilage destruction (Mankin score) in DMM surgery-induced OA mice. (d) Safranin-O/hematoxylin staining in the cartilage of C57BL/6 mice injected with empty adenovirus (Ad-C) or Ad-Epas1 (1 × 10⁹ plaque-forming units) (n=10 per group). Scale bar: 50 μm.