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. 2015 Dec 4;47(12):e197. doi: 10.1038/emm.2015.88

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Copyright © 2015 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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IL-6 and TNF-α have distinct effects on FLS and chondrocytes. (a and b) Mouse FLS (a) and chondrocytes (b) were infected with the indicated MOI of Ad-Epas1, and the levels of secreted IL-6 and TNF-α in the culture media were determined by ELISA. (c and d) The indicated amounts of recombinant mouse IL-6 protein were used to treat FLS (c) or chondrocytes (d) for 24 h, and the mRNA levels of Mmp3 and Mmp13 were detected by qRT-PCR. (e and f) Mouse FLS (e) and articular chondrocytes (f) were treated with the indicated doses of recombinant mouse TNF-α protein for 24 h, and the levels of the indicated catabolic factors were determined by qRT-PCR. Values are presented as means±s.e.m. (*P<0.01, **P<0.005).