Figure 4.

Effect of [D-Tyr¹¹]NT and antagonists on ${\text{I}}_{\text{h}}^{+}$ neurons. Panel 1: Current traces of glutamatergic EPSC recorded during superfusion of [D-Tyr¹¹]NT; control (1), with [D-Tyr¹¹]NT (0.01 μM) (2) and following the washout of [D-Tyr¹¹]NT (3) at a holding membrane potential of −70 mV in ${\text{I}}_{\text{h}}^{+}$ neurons (n = 6). Panel 2: Current traces of glutamatergic EPSC recorded during superfusion with SR142948 (0.1 μM) (1), with SR142948 and [D-Tyr¹¹]NT (0.01 μM) (2) and with SR142948 following the washout of (3) at a holding membrane potential of −70 mV in ${\text{I}}_{\text{h}}^{+}$ neurons (n = 5). Panel 3: Current traces of glutamatergic EPSC recorded during superfusion with SR48692 (0.1 μM) (1), with SR48692 and [D-Tyr¹¹]NT (0.01 μM) (2) and with SR48692 following the washout of [D-Tyr¹¹]NT (3) at a holding membrane potential of −70 mV in ${\text{I}}_{\text{h}}^{+}$ neurons (n = 4).