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. 2015 Dec 3;6:10053. doi: 10.1038/ncomms10053

Figure 5. Elucidation of structural dissimilarities between wt- and mt-neddylated Cul1–Rbx1 complexes by quantitative analysis of Cul1–Nedd8 interlinks.

Figure 5

MS1 spectra of (a) Nedd8K6–Cul1K410, (b) Nedd8K6–Cul1K464, (c) Nedd8K6–Cul1K493, (d) Nedd8K6–Cul1K701, (e) Nedd8K48–Cul1K493 and (f) Nedd8K48–Cul1K693. The mt form was d0-DMDSSO cross-linked, and the wt form was d10-DMDSSO cross-linked. (g) Proposed models for Nedd8-dependent conformational changes of the Cul1–Rbx1 complex.