FIGURE 4.

ASIC currents in SGN from P14–16 mice. (A) Top, Amiloride (Ami) blocks the peak of the ASIC current; Middle, FMRFamide (FMRF) increases the peak and sustained currents and reduces the desensitization rate; Bottom, St blocks the peak current, increases the sustained current and reduces the desensitization rate. (B) Bar plot summarizing the effects of the drugs from (A). The bars represent the means ± SE of the I_peak (black bars), the I_sus (light gray bars) or the τ_des (dark gray bars). The data are expressed as the percent-change relative to the control value (^∗P < 0.05, ^∗∗P < 0.01, and paired Student’s t-test).