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. 2015 Dec 3;6:10127. doi: 10.1038/ncomms10127

Figure 2. Evolutionary expansion of RBP short peptide motifs.

Figure 2

(a) Overlap of yeast and human mRNA interactome orthologs. (b) Definition of InParanoid ortholog groups of mRNA interactome RBPs. (c) Tripeptide motifs showing expansion in number between human RBPs compared with their orthologous yeast RBPs (FDR 0.2). (d) Average copy number of motifs from (c), calculated for yeast, C. elegans, D. melanogaster, D. rerio and human orthologous RBPs of the core mRNA interactome and for non-RNA-binding orthologous proteins (non-RNA binders). (e) Examples of orthologous RBPs with increased copy number of motifs from c. Protein sequences are not drawn to scale; the relative position of domains and motifs within proteins is retained.