FIGURE 3.

Kainate receptors cluster in remodeled bipolar cell dendrites and persist in the absence of residual photoreceptors in rd10 retina. (A–C) Clusters of Neto1 puncta in wild-type and rd10 outer retina. (D–F) Same regions as in (A–C) showing double labeling for Neto1 and secretagogin. Note that Neto1 puncta are associated with remodeled cone bipolar cell dendrites in both the early and late rd10 age groups (arrows). (G–I) Regions of outer retina double labeled for recoverin and Neto1 in wild-type and rd10 retina at the early time-point. Note the recoverin-labeled photoreceptor terminals in the wild-type retina (G). Some residual dysmoprhic cones (arrowheads) remain in the peripheral rd10 retina (H), however, in the central retina Neto1 clusters (arrow) remain despite the lack of any residual cones. Scale bar = 10 μm.