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. 2015 Dec 2;6:8953. doi: 10.1038/ncomms9953

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(a) Effects of the AIS and KA1 mutations on the trans-inhibition of AIS-KA1 on the KD-UBA activity. The assays were performed with 10 nM wild-type KD-UBA and 50 μM AIS-KA1 mutants. (b) Comparison of the catalytic activities of various KD-UBA mutants in the absence or presence of AIS-KA1. The assays were performed with 5 nM KD-UBA mutants and 50 μM wild-type AIS-KA1. (c) Activities of full-length SAD-A bearing various UBA and/or AIS mutations. Reactions were initiated by adding 5 nM indicated SAD-A proteins. (mean±s.e.m., n=3)