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. Author manuscript; available in PMC: 2016 Aug 28.
Published in final edited form as: Eur J Med Chem. 2015 Jun 16;101:384–390. doi: 10.1016/j.ejmech.2015.06.031

Table 2.

Minimum inhibitory concentration (MIC, in µM) of isonitrile compounds, linezolid, and vancomycin against methicillin-sensitive (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) strains.

Compound
Name		 MSSA1
(NRS72)		 MRSA
USA100		 MRSA
USA200		 MRSA
USA300		 MRSA
USA500		 MRSA
USA700		 MRSA
NRS119		 VISA1
NRS1 		VRSA2
VRS2
1 8 8 16 32 32 8 64 8 32
4a >128 >128 128 >128 >128 >128 >128 128 >128
5 8 8 64 >128 >128 16 >128 4 >128
6 16 16 16 32 16 16 32 8 32
7 32 32 32 >128 32 16 >128 16 64
8 8 8 8 16 8 4 16 4 16
9 8 16 16 32 16 8 64 8 32
10 8 16 16 32 16 16 64 8 16
11 8 8 8 16 8 4 >128 4 8
12 4 4 8 >128 8 2 8 2 8
13 16 2 4 4 32 4 4 2 32
14 4 8 2 16 >128 8 32 4 32
15 8 8 4 16 32 16 32 4 32
16 8 8 8 8 8 8 16 4 16
17 4 8 2 8 16 8 16 4 32
18 4 8 2 16 16 8 32 4 32
19 8 16 16 32 128 16 128 8 128
20 4 4 2 8 16 2 16 2 16
21 2 4 4 8 8 4 8 2 8
22 8 16 16 32 16 16 >128 8 32
23 16 4 4 16 32 8 64 4 32
24 >128 - >128 >128 >128 - >128 - >128
25 2 4 4 8 8 8 16 4 8
26 8 16 64 >128 >128 16 >128 4 >128
27 64 64 64 16 64 32 128 64 32
28 64 32 64 32 64 64 128 128 128
29 64 128 128 32 64 128 128 64 64
30 64 32 32 16 32 32 64 64 32
31 64 32 64 32 64 64 64 64 64
32 16 16 32 8 32 16 64 32 8
33 64 32 32 32 32 32 64 64 64
34 64 32 64 32 64 64 32 32 64
35 2 8 8 4 4 8 4 8 4
36 16 32 32 16 >128 16 64 32 32
37 4 4 32 4 16 64 >128 >128 >128
42 >128 >128 >128 >128 >128 >128 >128 >128 >128
43 >128 >128 >128 >128 >128 >128 >128 >128 >128
46 >128 16 16 >128 >128 16 >128 8 >128
49 >128 16 16 >128 >128 16 64 4 >128
50 >128 >128 >128 >128 >128 >128 >128 >128 >128
51 16 16 64 64 32 16 32 4 64
52 >128 >128 32 >128 >64 >64 >128 8 >64
53 64 4 16 4 128 32 2 2 64
Linezolid 2 <1 2 2 <1 2 64 <1 <1
Vancomycin <1 2 - - 4 - - 8 128
1

VISA = Vancomycin-intermediate Staphylococcus aureus.

2

VRSA = Vancomycin-resistant Staphylococcus aureus.