Figure 1. Schematic of methodology applied in this study.

Step I: Integration of genomic, DNA methylomic, and transcriptomic data to identify three candidate gene groups; Step II: Identification of gene ontology (GO) function term and corresponding gene groups of interest based on GO enrichment analysis; Step III: Identification of genes within the identified functional groups significantly afflicted by genetic or epigenetic dysregulation, by applying random walk with restart algorithm in the merged network. Step IV: Survival analysis of identified significant genes to evaluate their prognostic value.