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. 2015 Dec 22;5:18616. doi: 10.1038/srep18616

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(a) The biggest connected component (BCC) of DPRN containing 3,271 developmental process related genes (DPRGs) and 20,652 edges. DEGs with abnormal promoter methylation and DEGs with somatic mutation in DPRN were regarded as source nodes, and the rest of DPRGs in the network were target nodes. (b) The subgraph of DPRN composed of 37 significant genes retrieved via random walk with restart.