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. 2015 Dec 22;5:17559. doi: 10.1038/srep17559

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Copyright © 2015, Macmillan Publishers Limited

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(a,b) Western blot analysis showed decreased levels of PCSK9 in the SBA rat fetuses (p < 0.001). (c) PCSK9 was detectable in serum, AF and the spinal cord and placenta by Western blot analysis. Protein extracts revealed one band (60 kDa) in spinal cord and two bands (60, 50 kDa) in serum, AF and placenta. (d–i) Distribution of PCSK9 immunostaining in the spinal cords and placentas of rat embryos at E15. PCSK9 immunoreactivity was mainly localized to the cytoplasm and nuclear (red arrow) in the spinal cords and the placentas. PCSK9 showed downregulated expression in SBA embryos compared with normal ones. (d) Spinal cord of normal embryos. (e) Spinal cord of SBA embryos. (f) The maternal side of placenta of normal embryos. (g) The maternal side of placenta of SBA embryos. (h) The fetal side of a placenta of normal embryos. (i) The fetal side of a placenta of SBA embryos. Magnification: ×200; Scale bars = 50 μm.