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. 2015 Dec 22;5:18789. doi: 10.1038/srep18789

Figure 1. Demonstration of multidrug resistance in PTX- resistant ovarian cancer cells (A2780/T).

Figure 1

(A) Chemical Structures of nobiletin. (B) Cytotoxicity of nobiletin alone in pairs of A2780/T or A2780 cells. (C) The cells were treated with various concentrations of paclitaxel (PTX) and doxorubicin (DOX) for 48 hours. Cell growth was determined using the SRB assay. The expression of ABCB1 transporter in A2780 and A2780/T cells was analyzed at level of both MDR1 mRNA by RT-qPCR (D) and P-gp protein level by Western blotting (E). (### Significantly different from A2780 cells with P < 0.001). Protein expression levels after normalized relatively to that of β-actin.