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. 2015 Dec 22;5:18789. doi: 10.1038/srep18789

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(A) The MDR1 mRNA level was determined by RT-PCR in A2780/T cells or A2780 cells. Combination treatment of paclitaxel and nobiletin did not influence P-gp expression levels, but unregulated the p53 expression (B) and reduced the expression level of Nrf2 (C) as well as the phosphorylation of AKT/ERK (B) by Western blot assay.