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. 2015 Dec 22;5:18789. doi: 10.1038/srep18789

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Nobiletin increased the directional transport of Rho123 (5 μM) (A) and DOX (10 μM) (B) across Caco-2 cell monolayers. Nobiletin decreased the efflux ratio of Rho123 (5 μM) (A) and DOX (10 μM) in Caco-2 cell. □ AP → BL transport, ■ BL → AP transport. ΔΔ or **P < 0.01, ΔΔΔ or ***P < 0.001, significantly different from those obtained in the absence of nobiletin.