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. 2015 Oct 8;65(1):149–163. doi: 10.2337/db15-0108

Figure 5.

Figure 5

High glucose induces UPR and ER stress through miR-200b. Protein levels of p-PERK, PERK, p-eIF2α, eIF2α, p-IRE1α, IRE1α, CHOP, CITED2, and β-actin in cells transfected with the control oligo or the miR-200b mimic under 5 mmol/L glucose conditions (A and B) and in cells transfected with the control oligo or the miR-200b inhibitor under 5 mmol/L or 25 mmol/L glucose conditions (C and D). Experiments were repeated three times (n = 3), and the quantification of the data is shown in the bar graphs. *Significant differences (P < 0.05) compared with the other group or groups.