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CITED2 silencing promotes UPR and ER stress. CITED2 protein (A) and mRNA levels (B) in cells transfected with different concentrations of the control siRNA and the CITED2 siRNA. C: Changes in p-PERK, PERK, p-eIF2α, eIF2α, p-IRE1α, IRE1α, and CHOP protein expression in cells transfected with the CITED2 siRNA. Experiments were repeated three times (n = 3), and the quantification of data is shown in the bar graphs. *Significant differences (P < 0.05) compared with the other groups.
