Fig 6. Multi-patch interaction sites of selected proteins.
The experimental interface residues are colored according to TJET computed by iJET2. iJET2 predictions were obtained from a consensus of 2 runs out of 10. They are colored according to the scoring scheme used: SC1 in orange, SC2 in purple and SC3 in cyan. They were automatically chosen by iJET2 clustering algorithm (full procedure). The residues detected by both scoring schemes are colored in cyan (SC3). VORFFIP predictions are colored in dark green. The insert at the bottom shows the most frequent types of multi-patch predictions by JET2. Overlaps are computed as: o i,j = #(pred i ∩ pred j)/#(pred i), where pred i and pred j represent the residues predicted at the interface by SCi and SCj respectively. (a,d) o 1/2,3 < 60% & o 3,1/2 ≥ 60%, (b,e) o 1/2,3 < 30% & o 3,1/2 < 30%, (c,f) o 1/2,3 ≥ 60% & o 3,1/2 ≥ 60%. The proportions of predictions corresponding to each case, among all SC1-SC3 predictions (upper row) or all SC2-SC3 predictions (lower row), are given for Huang (H) and PPDBv4 (P).