Table 3. Previous SPECT studies investigated cerebral perfusion of TGA patient.
| Author (year) | Patient (No) | SPECT protocol | Study design | Results |
|---|---|---|---|---|
| Stillhard (1990)[57] | 1 | 99m-Tc-HMPAO | Case report | Reversible bitemporal hypoperfusion |
| Visual reading | Longitudinal f/u | |||
| Gondenberg (1991)[31] | 1 | 99m-Tc-HMPAO | Case report | Reversible bilateral thalamic (left>right) hypoperfusion |
| Quantitative analysis | Longitudinal f/u | Persistent left frontal hypoperfusion | ||
| Evans (1993)[22] | 1 | 99m-Tc-HMPAO | Case report | Reversible bilateral postero-medial hypoperfusion |
| Visual reading | Longitudinal f/u | |||
| Lin (1993)[58] | 1 | 99m-Tc-HMPAO | Case report | Reversible multiple perfusion defects in both occipital lobes, the medial left temporal lobe, and the left thalamus |
| Visual reading | Longitudinal f/u | |||
| Jung (1996)[26] | 1 | 99m-Tc-ECD | Case report | Reversible hyperperfusion in the posterior caudal region of the right medial temporal lobe |
| Visual reading | Longitudinal f/u | |||
| Quantitative analysis (ROI) | ||||
| Jovin (2000)[24] | 1 | 99m-Tc-bicisate | Case report | Reversible bilateral medial temporal hypoperfusion |
| Visual reading | Longitudinal f/u | |||
| Laloux (1992) [27] | 5 | 99m-Tc-HMPAO | Case series | |
| Visual reading | Cross-sectional | Left temporal, parietotemporal hypoperfusion | ||
| Longitudinal f/u | Persistent left temporal hypoperfusion | |||
| Matsuda (1993)[28] | 1 | 99m-Tc-HMPAO | Case report | Reversible left medial temporal hyperperfusion |
| Visual reading | Longitudinal f/u | |||
| Sakashita (1997)[59] | 6 | 99m-Tc-HMPAO | Case series | Reversible occipital and cerebellar hyperperfusion |
| Visual reading | Longitudinal f/u | Reversible thalamic, cerebellar or putamenal hypoperfusion | ||
| Takeuch (1998)[60] | 1 | 99m-Tc-ECD with acetazolamide (ACZ) | Case report | Reversible left medial temporal and thalamic poor vasodilatory reactivity to ACZ and hypoperfusion |
| Visual reading | Longitudinal f/u | |||
| Nardone (2004)[61] | 13 | 99m-Tc-HMPAO | Case series | Reversible or persistent thalamic, striatal or temporal hypoperfusion |
| Visual reading | Longitudinal f/u | |||
| Chung (2009)[36] | 7 | 99m-Tc-ECD | Case-control study | Reversible bilateral inferior, middle frontal hypoperfusion |
| Voxel-based whole brain analysis | Longitudinal f/u | Reversible superior temporal, precentral and postcentral hypoperfusion (left>right) | ||
| Reversible middle, superior temporal, inferior frontal, cerebellar and thalamic hyperperfusion (right>left) | ||||
| Yamane (2008)[33] | 1 | 123 I-IMP | Case report | Reversible diffuse cerebral hypoperfusion |
| Visual reading | Longitudinal f/u | |||
| Current study | 22 | 99m-Tc-ECD | Longitudinal f/u | Hypoperfusion in the left precuneus, inferior temporal and superior parietal area. |
| Voxel-based whole brain analysis | ||||
| Quantitative analysis (VOI) |
SPECT, Single-photon emission computed tomography; 99m-Tc-HMPAO, hexamethylpropyleneamineoxim; 99m-Tc-ECD, ethyl cysteinate dimer; ROI, region of interest; VOI, volume of interest;
123I-IMP, Iodine-123-labeled N-isopropyl-4-iodoamphetamine.