Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2016 Mar 1.

Published in final edited form as: Nat Rev Endocrinol. 2015 Jan 6;11(3):171–181. doi: 10.1038/nrendo.2014.226

TSHR displayed on fibrocytes generated from PBMCs can initiate cytokine production. Cultures cells from a patient with GD were treated with bTSH (5 mU/ml) or IL-1β (10 ng/ml) for 48h. Medium was subjected to ELISAs specific for IL-6 (left panel) or TNF- α (right panel). Data are expressed as the mean ± SEM of three replicate culture wells. *, P < 0.001. (Reprinted with permission; Douglas et al. Increased generation of fibrocytes in thyroid-associated ophthalmopathy, Reference 6, Copyright 2010. The Endocrine Society.)

TSHR displayed on fibrocytes generated from PBMCs can initiate cytokine production. Cultures cells from a patient with GD were treated with bTSH (5 mU/ml) or IL-1β (10 ng/ml) for 48h. Medium was subjected to ELISAs specific for IL-6 (left panel) or TNF- α (right panel). Data are expressed as the mean ± SEM of three replicate culture wells. *, P < 0.001. (Reprinted with permission; Douglas et al. Increased generation of fibrocytes in thyroid-associated ophthalmopathy, Reference 6, Copyright 2010. The Endocrine Society.)