Fig. 2.
Gel mobility shift analysis of TRAP-trp leader RNA interaction. 5′ end-labeled trp leader RNA (0.1 nM) was incubated with the concentration of TRAP shown at the top of each lane. Samples were loaded onto 6% polyacrylamide gels with a 37.5:1 acrylamide:bisacyrylamide ratio. Positions of bound and free RNA are shown. (a) TBE buffering system. (b) Tris-glycine buffering system. The Tris-glycine buffering system gave superior results in this particular case. The Kd for this reaction was calculated to be 17 nM TRAP.