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. 2015 Dec 21;10(12):e0145397. doi: 10.1371/journal.pone.0145397

Fig 4. B.pseudomallei- LPS-induced neutrophil influx is dependent on TLR4 in mice.

Fig 4

Wild-type (WT), TLR2-/-, TLR4-/- and TLR2x4-/- mice were inoculated intranasally with 10 ug LPS of B.pseudomallei 1026b and analysed 6h later for lung neutrophil influx in bronchoalveolar fluid (BALF) (A). Representative Giemsa stained BALF slides are shown of WT, TLR2-/-, TLR4-/- and TLR2x4-/- mice obtained 6h post-LPS administration (magnification 20x) (B). Following a Kruskal-Wallis test, Mann-Whitney U-tests were performed. Data are presented as means ± SEM. Results of two independent experiments were pooled (n = 16 per group). ***P< 0.001 vs. WT.