Table 2. Correlation between KRAS, NRAS, BRAF and PIK3CA mutations and clinicopathological parameters in CRC.
| |
Total number N = 1, 110 (%) | KRAS status |
NRAS status |
BRAF status |
PIK3CA status |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clinicopathological features | Mutation n (%) | Wild-type n (%) | P value | Mutation n (%) | Wild-type n (%) | P value | Mutation n (%) | Wild-type n (%) | P value | Mutation n (%) | Wild-type n (%) | P value | ||
| Gender | Male | 649 (58.6) | 286 (44.1) | 363 (55.9) | 0.288 | 25 (3.9) | 624 (96.1) | 0.964 | 18 (2.8) | 631 (97.2) | 0.507 | 22 (3.4) | 627 (96.6) | 0.791 |
| Female | 461 (41.4) | 218 (47.3) | 243 (52.7) | 18 (3.9) | 443 (96.1) | 16 (3.5) | 445 (96.5) | 17 (3.7) | 444 (96.3) | |||||
| Age (years) | Mean ± SD | 62 (18–96) | 62.10 ± 12.2 | 62.12 ± 12.2 | 0.185 | 62.28 ± 13.9 | 61.54 ± 12.1 | 0.695 | 61.35 ± 11.0 | 61.57 ± 12.2 | 0.918 | 60.97 ± 11.3 | 61.59 ± 12.2 | 0.758 |
| Tumor site | Right | 249 (22.4) | 133 (53.4) | 116 (46.6) | <0.001 | 9 (3.6) | 240 (96.4) | 0.659 | 21 (8.4) | 228 (91.6) | <0.001 | 14 (5.6) | 235 (94.4) | 0.115 |
| Left | 314 (28.3) | 110 (35.0) | 204 (65.0) | 10 (3.2) | 304 (96.8) | 6 (1.9) | 308 (98.1) | 10 (3.2) | 304 (96.8) | |||||
| Rectum | 547 (49.3) | 261 (47.7) | 286 (52.3) | 24 (4.4) | 523 (95.6) | 7 (1.3) | 540 (98.7) | 15 (2.7) | 532 (97.3) | |||||
| Histological type | Tubular | 1024 (92.3) | 451 (44.0) | 573 (56.0) | 0.002 | 42 (4.1) | 982 (95.9) | 0.175 | 29 (2.8) | 995 (97.2) | 0.123 | 38 (3.7) | 986 (96.3) | 0.357 |
| Mucinous | 86 (7.7) | 53 (61.6) | 33 (38.4) | 1 (1.2) | 85 (98.8) | 5 (5.8) | 81 (94.2) | 1 (1.2) | 85 (98.8) | |||||
| Differentiation | Well | 211 (19.0) | 102 (48.3) | 109 (51.7) | 0.023 | 10 (4.7) | 201 (95.3) | 0.633 | 2 (0.9) | 209 (99.1) | <0.001 | 13 (6.2) | 198 (93.8) | 0.063 |
| Moderate | 816 (73.5) | 376 (46.1) | 440 (53.9) | 31 (3.8) | 785 (96.2) | 21 (2.6) | 795 (97.4) | 23 (2.8) | 793 (97.2) | |||||
| Poor | 83 (7.5) | 26 (31.3) | 57 (68.7) | 2 (2.4) | 81 (97.6) | 11 (13.3) | 72 (86.7) | 3 (3.6) | 80 (96.4) | |||||
| Depth of invasion | T1 | 24 (2.2) | 11 (45.8) | 13 (54.2) | 0.694 | 3 (12.5) | 21 (87.5) | 0.065 | 1 (4.2) | 23 (95.8) | 0.074 | 0 (0) | 24 (100.0) | 0.512 |
| T2 | 188 (16.9) | 90 (47.9) | 98 (52.1) | 4 (2.1) | 184 (97.9) | 6 (3.2) | 182 (96.8) | 9 (4.8) | 179 (95.2) | |||||
| T3 | 841 (75.8) | 374 (44.5) | 467 (55.5) | 35 (4.2) | 806 (95.8) | 22 (2.6) | 819 (97.4) | 29 (3.4) | 812 (96.6) | |||||
| T4 | 57 (5.1) | 29 (50.9) | 28 (49.1) | 1 (1.8) | 56 (98.2) | 5 (8.8) | 52 (91.2) | 1 (1.8) | 56 (98.2) | |||||
| Lymph node metastasis | Yes | 485 (43.7) | 227 (46.8) | 258 (53.2) | 0.410 | 20 (4.1) | 465 (95.9) | 0.704 | 19 (3.9) | 466 (96.1) | 0.135 | 14 (2.9) | 471 (97.1) | 0.318 |
| No | 625 (56.3) | 277 (44.3) | 348 (55.7) | 23 (3.7) | 602 (96.3) | 15 (2.4) | 610 (97.6) | 25 (4.0) | 600 (96.0) | |||||
| Distant metastasis | Yes | 32 (2.9) | 10 (31.3) | 22 (68.7) | 0.103 | 3 (9.4) | 29 (90.6) | 0.123 | 4 (12.5) | 28 (87.5) | 0.009 | 3 (9.4) | 29 (90.6) | 0.099 |
| No | 1078 (97.1) | 494 (45.8) | 584 (54.2) | 40 (3.7) | 1038 (96.3) | 30 (2.8) | 1048 (97.2) | 36 (3.3) | 1042 (96.7) | |||||
| TNM stage | I | 159 (14.3) | 77 (48.4) | 82 (51.6) | 0.209 | 4 (2.5) | 155 (97.5) | 0.329 | 7 (4.4) | 152 (95.6) | 0.019 | 7 (4.4) | 152 (95.6) | 0.153 |
| II | 469 (42.3) | 204 (43.5) | 265 (56.5) | 19 (4.2) | 450 (95.8) | 8 (1.7) | 461 (98.3) | 18 (3.8) | 451 (96.2) | |||||
| III | 450 (40.5) | 213 (47.3) | 237 (52.7) | 17 (3.8) | 433 (96.2) | 15 (3.3) | 435 (96.7) | 11 (2.4) | 439 (97.6) | |||||
| IV | 32 (2.9) | 10 (31.3) | 22 (68.7) | 3 (9.4) | 29 (90.6) | 4 (12.5) | 28 (87.5) | 3 (9.4) | 29 (90.6) | |||||