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. Author manuscript; available in PMC: 2015 Dec 22.
Published in final edited form as: Nat Chem Biol. 2014 Sep 7;10(10):853–860. doi: 10.1038/nchembio.1629

Figure 3. Selectivity and off-target binding modes of SCH772984.

Figure 3

a) Inhibitor selectivity determined using KinomeScan22. Binding affinities of the inhibitor are represented as spheres mapped onto the kinase phylogenetic tree. The sphere radius corresponds to inhibitor affinities as indicated in the figure. b) Detailed interactions of SCH772984 with the haspin ATP binding pocket. c) Schematic illustration for superimposition of ERK2 and haspin structures reveals the distinct accommodations of the inhibitor. d) Detailed interactions of SCH772984 with JNK1. e) Superimposition of the ERK2 and JNK1 complexes.