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. Author manuscript; available in PMC: 2015 Dec 22.
Published in final edited form as: Methods. 2013 Oct 22;66(1):106–119. doi: 10.1016/j.ymeth.2013.10.008

Table 1.

List of allergens contained on the MeDALL allergen-chip. Allergen-sources, allergen-names according to IUIS-standard, purification from extracts (natural allergens) or production in expression systems (recombinant allergens), glycosylation and allocation to different allergen-families are shown. Proteins that were provided by collaborating groups are highlighted by coloured boxes (column “Allergen”). For wheat allergens, # indicates the number of the respective clones. Some allergen families represented on the chip by several allergen molecules are highlighted by coloured boxes (column “Function of the protein/Allergen family”). In the separate part of the list, allergens that replaced proteins from the first variant of the microarray (Proteins No. 164–176) are listed.

Version 1 of the MeDALL-Chip
No. Allergen-source Allergen Rec. or
natural
CCD Route of
exposure
Function of the protein/Allergen family
1 Birch Bet v 1 R inh PR-10
2 Bet v 2 R inh Profilin
3 Bet v 4 R inh Polcalcin
4 Alder Aln g 1 R inh PR-10
5 Olive Ole e 1 R inh Ole e 1-related protein
6 Ole e 7 N inh nsLTP, type 1
7 Ole e 9 R inh Glucanase
8 Japanese cedar Cry j 1 N CCD inh Pectate lyase
9 Cypress Cup a 1 N CCD inh Pectate lyase
10 Plane tree Pla a 1 R inh Invertase Inhibitor
11 Pla a 2 N CCD inh Polygalacturonases
12 Pla a 3 R inh nsLTP, type 1
13 Timothy grass Phl p 1 R inh Grass group 1 (Beta-Expansin)
14 Phl p 2 R inh Grass group 2/3
15 Phl p 4 N CCD inh Grass group 4 (Berberine bridge enzyme)
16 Phl p 5b R inh Grass group 5
17 Phl p 6 R inh Grass group 5/6
18 Phl p 7 R inh Calcium-binding proteins (Polcalcin)
19 Phl p 11 R inh Ole e 1-related protein
20 Phl p 12 R inh Profilin
21 Bermuda grass Cyn d 1 N CCD inh Grass group 1 (Beta-Expansin)
22 Ragweed Amb a 1 N inh Pectate lyase
23 Mugwort Art v 1 N inh Defensin-like protein
24 Art v 3 N inh nsLTP, type 1
25 Goosefoot Che a 1 R inh Ole e 1-related protein
26 Annual mercury Mer a 1 R inh Profilin
27 Plantain Pla l 1 R inh Ole e 1-related protein
28 Wall pellitory Par j 2 R inh nsLTP, type 1
29 Saltwort Sal k 1 N inh Pectin methylesterase
30 Latex Hev b 1 R inh, skin Rubber elongation factor
31 Hev b 3 R inh, skin Small rubber particle protein
32 Hev b 5 R inh, skin Acidic protein
33 Hev b 6.01 R inh, skin Hevein (Prohevein)
34 Hev b 8 R inh, skin Profilin
35 Alternaria Alt a 1 R inh Acidic glycoprotein
36 Alt a 6 R inh Enolase
37 Aspergillus Asp f 1 R inh Mitogillin family (Ribonuclease)
38 Asp f 3 R inh Peroxysomal protein
39 Asp f 6 R inh Mn superoxide dismutase
40 Cladosporium Cla h 8 R inh Mannitol dehydrogenase
41 House dust mite Der p 1 N inh Group 1 mite allergens (Cysteine protease)
42 Der f 1 N inh Group 1 mite allergens (Cysteine protease)
43 Der p 2 R inh Group 2 mite allergens (NPC2 family)
44 Der f 2 R inh Group 2 mite allergens (NPC2 family)
45 Der p 4 R inh Group 4 mite allergens (Alpha-amylase)
46 Der p 5 R inh Group 5 mite allergens
47 Der p 7 R inh Group 7 mite allergens
48 Der p 10 R inh Group 10 mite allergens (Tropomyosin)
49 Der p 11 R inh Group 11 mite allergens (Paramyosin)
50 Der p 14 R inh Vitellogenin (Apolipophorins)
51 Der p 15 R inh Chitin-binding domain
52 Der p 18 R inh Chitin-binding domain
53 Der p 21 R inh Group 21 mite allergens
54 Der p 23 R inh Chitin-binding domain
55 clone 16 R inh Chitin-binding domain
56 Storage mite Lep d 2 R inh Group 2 mite allergens (NPC2 family)
57 Blomia tropicalis Blo t 5 R inh Group 5 mite allergens
58 Cockroach Bla g 1 R inh Cockroach group 1
59 Bla g 2 R inh Aspartic protease
60 Bla g 5 R inh Glutathione S-transferase
61 Bla g 7 N inh Tropomyosin
62 Anisakis Ani s 1 R f Serine protease inhibitor
63 Ani s 3 R f Tropomyosin
64 Cat Fel d 1 R inh Uteroglobin
65 Fel d 2 N inh Serum Albumin
66 Fel d 4 R inh Lipocalin
67 Dog Can f 1 R inh Lipocalin
68 Can f 2 R inh Lipocalin
69 Can f 3 N inh Serum Albumin
70 Can f 4 R inh Lipocalin (Odorant-binding protein)
71 Can f 5 R inh Arginine Esterase (Trypsin-like serine protease)
72 Can f 5 R inh Arginine Esterase (Trypsin-like serine protease)
73 Can f 6 R inh Lipocalin
74 Horse Equ c 1 R inh Lipocalin
75 Equ c 3 N inh Serum Albumin
76 Mouse Mus m 1 N inh Lipocalin
77 Peanut Ara h 1 N f Storage protein, 7S globulin (Vicilins)
78 Ara h 1 R f Storage protein, 7S globulin (Vicilins)
79 Ara h 2 R f Storage protein, 2S albumin
80 Ara h 3 N f Storage protein, 11S globulin (Legumins)
81 Ara h 3 R f Storage protein, 11S globulin (Legumins)
82 Ara h 6 N f Storage protein, 2S albumin
83 Ara h 6 N f Storage protein, 2S albumin
84 Ara h 8 R f PR-10
85 Ara h 9 R f nsLTP, type 1
86 Hazelnut Cor a 1.0401 R f, inh PR-10
87 Cor a 8 R f nsLTP, type 1
88 Cor a 9 N f Storage protein, 11S globulin (Legumins)
89 Walnut Jug r 1 R f Storage protein, 2S albumin
90 Jug r 2 N CCD f Storage protein, 7S globulin (Vicilins)
91 Jug r 3 R f nsLTP, type 1
92 Almond Pru du 3 R f nsLTP, type 1
93 Pru du 4 R f Profilin
94 Pru du 6 N f Storage protein, 11S globulin (Legumins)
95 Pru du 6.01 R f Storage protein, 11S globulin (Legumins)
96 Pru du 6.02 R f Storage protein, 11S globulin (Legumins)
97 Cashew nut Ana o 1 R f Storage protein, 7S globulin (Vicilins)
98 Ana o 2 R f Storage protein, 11S globulin (Legumins)
99 Ana o 2 N f Storage protein, 11S globulin (Legumins)
100 Ana o 2 R f Storage protein, 11S globulin (Legumins)
101 Ana o 3 R f Storage protein, 2S albumin
102 Pistachio Pis v 3 R f Storage protein, 7S globulin (Vicilins)
103 Brazil nut Ber e 1 R f Storage protein, 2S albumin
104 Sesame Ses i 1 N f Storage protein, 2S albumin
105 Soy Gly m 4 R f PR-10
106 Gly m 5 N f Storage protein, 7S globulin (Vicilins)
107 Gly m 6 N f Storage protein, 11S globulin (Legumins)
108 Wheat Tri a 14 R f, inh nsLTP, type 1
109 Tri a 14 R f, inh nsLTP, type 1
110 Tri a 19.0101 R f Storage protein, Omega 5 gliadin
111 Tri a aA TI N f, inh Alpha-Amylase / Trypsin Inhibitors
112 m43 R f Fragment of HMW Glutenin Bx7
113 m82 R f Fragment of HMW Glutenin Bx7
114 Tri a 36 (191-369) R f, inh Fragment of LMW Glutenin
115 Tri a 36 R f, inh LMW Glutenin
116 Tri a 37 R f Thionins (Alpha-purothionin)
117 Tri a 39 (#10) R inh Serine protease inhibitors
118 Tri a Trx (#37) R inh Oxidoreductases (Thioredoxin)
119 Tri a GST (#38) R inh Glutathione S-transferases
120 Tri a 32 (#112) R inh Peroxiredoxins (1-Cys-peroxiredoxin)
121 Tri a 12 (#123) R f, inh Profilin
122 Tri a DH (#126) R inh Dehydrins
123 Buckwheat Fag e 2 N f Storage protein, 2S albumin
124 Kiwi Act d 1 N f Cysteine protease
125 Act d 2 N f Thaumatin-like protein
126 Act d 5 N f Kiwellin
127 Act d 8 R f PR-10
128 Apple Mal d 1 R f PR-10
129 Peach Pru p 1 R f PR-10
130 Pru p 3 R f, skin nsLTP, type 1
131 Celery Api g 1 R f PR-10
132 Pineapple Ana c 2.0101 N CCD f, inh Bromelain ( MUXF3, CCD-Marker)
133 Cow’s Milk Bos d 4 N f Alpha-lactalbumin
134 Bos d 5 N f Beta-lactoglobulin
135 Bos d 6 N f, inh Serum Albumin
136 Bos d 8 N f Caseins
137 Bos d Lactoferrin N f Transferrin
138 Bos d 4 N f Alpha-lactalbumin
139 Bos d 5 N f Lipocalin (Beta-lactoglobulin)
140 Bos d 6 N f, inh Serum Albumin
141 Bos d 8 N f Caseins (α-, β-, κ-casein)
142 Bos d 9 R f Caseins (αS1-casein)
143 Bos d 10 R f Caseins (αS2-casein)
144 Bos d 11 R f Caseins (β -casein)
145 Bos d 12 R f Caseins (κ-casein)
146 Bos d Lactoferrin N f Transferrin
147 Egg white Gal d 1 N f Ovomucoid
148 Gal d 2 N f Ovalbumin
149 Gal d 3 N f Ovotransferrin (Conalbumin)
150 Egg yolk/chicken Gal d 5 N f, inh Serum Albumin
151 Codfish Gad c 1 R f Parvalbumin
152 Shrimp Pen m 1 N f Tropomyosin
153 Pen m 2 N f Arginine Kinase-like protein
154 Pen m 4 N f Calcium-binding proteins (Sarcoplasmic)
155 Bee Api m 1 R syst Insect venom, Phospholipase A2
156 Api m 1 R syst Insect venom, Phospholipase A2
157 Api m 2 R syst Insect venom, Hyaluronidase
158 Api m 4 N syst Melittin
159 Api m 4 N syst Melittin
160 Wasp Ves v 1 R syst Insect venom, Phospholipase A1
161 Ves v 5 R syst Insect venom, Antigen 5
162 Ves v 5 R syst Insect venom, Antigen 5
163 Paper wasp Pol d 5 R syst Insect venom, Antigen 5
164 Bacterial Toxins Sem R skin, inh
165 SspB R skin, inh
166 Sec R skin, inh
167 HlgC R skin, inh
168 Tsst R skin, inh
169 Hlb R skin, inh
170 Plc R skin, inh
171 GlpQ R skin, inh
172 Hla R skin, inh
173 Ssl11 R skin, inh
174 Sei R skin, inh
175 Seb R skin, inh
176 Control-protein MBP R - Maltose binding protein
Version 2 of the MeDALL-Chip (exchanged allergens)
164 Olive Ole e 5 R inh Superoxide dismutases
165 Ole e 6 R inh Oleaceae group 6
166 Ole e 8 R inh Calcium-binding proteins (Polcalcin)
167 Ole e 10 R inh Glycosyl hydrolases
168 Wheat Tri a gamma gliadin (GG1) R f Gamma-gliadins
169 Peptide 4 R (peptide) f Peptides from gamma-gliadin 1
170 Peptide 18 R (peptide) f Peptides from gamma-gliadin 1
171 Clone 79 R f Gamma-gliadins
172 Clone 85 R f Gamma-gliadins
173 Clone 110 R f Gamma-gliadins (Fragment)
174 Tri a bA R f beta-Amylases
175 Avenin-like protein R f Avenin
176 Human htTG2 R - Human tissue transglutaminase