| Cardiac infarction |
Enhancement of cardiac function |
MSC-mediated secretion of IL-10 |
[11] |
| Cardiac infarction |
Reduced infarction size, improved LV function, |
Enhancement of angiogenetic factors such as VEGF, reduction of apoptosis |
[32] |
| Cardiac infarction |
Improved LVEF, increase in angiogenesis |
CXCR-4-SDF-1 |
[33] |
| Cardiac infarction |
Decreased LV dilatation and dysfunction |
Attenuated IL-6 and TNFα production Increased expression of IL-10 |
[17] |
| Cardiac infarction |
Increased fractional shortening and LVEF |
VEGF |
[34] |
| Cardiac infarction |
Infarct healing |
Modulation of macrophage phenotype → IL-10, IL-6, TNFα |
[35] |
| Cardiac infarction |
Improved LV function |
Increased IL-10 |
[18] |
| Cardiac infarction |
Collagen formation |
IL-6 |
[36] |
| Cardiac infarction |
Survival after AMI |
low IL-6 level |
[37] |
| Cardiac infarction |
Collateral remodeling |
VEGF |
[38] |
| Type 1 diabetes mellitus |
Repair the destroyed islets in diabetic mice |
MSC differentiation and immunomodulatory effects |
[39] |
| Arthritis |
Decrease in cartilage erosion |
IL-4, IL-10, IFNγ |
[40] |
| Arthritis |
Improved arthritis symptoms |
Decrease in TNFα and inflammatory cells, Increased expressions of anti-inflammatory cytokines (IL-10, IP-10 and CXCR3) |
[41] |
| Traumatic Brain Injury |
Improvement in neurological function |
Reduction of inflammatory cells and proinflammatory cytokines, increase in anti-inflammatory cytokines |
[42] |
| Abdominal Aortic Aneurysm formation |
Attenuated formation |
IL-17 production |
[43] |
| Spinal cord compression Injury |
Promotes tissue sparing |
NGF |
[44] |
| Acute lung injury |
Reduced collagen deposition and neutrophilic infiltration |
Decrease in pro-inflammatory cytokines (IL-1β, IL-6, TNFα) and VEGF, nitrate and nitrite. |
[45] |
| Acute kidney injury |
Improved kidney function |
IL-1β, IL-6, TNFα, IL-4, |
[46] |
| Cerebral ischemia |
Decrease in neuronal apoptosis and improved neurological function |
Increase in IL-10 expression |
[47] |
