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. 2015 Dec 21;8:651. doi: 10.1186/s13071-015-1266-7

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© González-Cerón et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Haplotype networks of P. vivax genes encoding merozoite surface proteins in southern Mexico, 2006–2007. The haplotype network for each gene marker is shown. Each circle represents one haplotype and the circle size indicates frequency. The mutational steps are indicated by the short marks crossing the connection lines. Each color indicates a particular combined haplotype (dbp _II- ama1 _I-II-msp1 ₄, n = 16; coded by letters A → P). For example, isolates in dark green had the combined haplotype dh1-ah1-mh1, which was highly frequent and only detected in 2007. Meanwhile, isolates in intense pink and orange had a very different configuration (dh1, ah2 and mh3 or mh5), and haplotypes G, N, O and P had a distinctive and unique configuration