Table 1.
Patients characteristic
| MA.20 [10] | EORTC [12] | French [13] | |
|---|---|---|---|
| Recruitment years | 2000 - 2007 | 1996 - 2004 | 1991 - 1997 |
| Number of patients | 1832 | 4004 | 1334 |
| Median age | 54 | 54 | 57 |
| Node positive | 90 % | 56 % | 75 % |
| Breast surgery | 100 % breast conserving | 76 % breast conserving | 100 % mastectomy |
| CHX | 91 % | 55 % | 61 % |
| ER/PR negative | 32 % | 40 % | 7 % |
| Unknown ER/PR Status | n.a. | n.a. | 40 % |
| Her-2neu | n.a. | n.a. | n.a. |
| Main inclusion criteria | N+ or high risk* N0 any location | N+ or medial tumor | N+ or medial/central tumor |
| Breast/chest wall | Both arms: | Both arms: | Both arms: according to practice of the center |
| 50 Gy/25 fx | 50 Gy/25 fx | ||
| Medial supraclavicular nodes | Experimental arm: 45Gy/25 fx | Experimental arm: 50 Gy/25 fx | All patients: dose and fractionation according to practice of the center |
| Internal mammary nodes | Experimental arm: 45Gy/25 fx | Experimental arm: 50 Gy/25 fx | Experimental arm: 45 Gy/20 fx |
*= > = 5 cm tumor, > = 2 cm tumor, and <10 axillary nodes removed with ER-, G3, or lymph vascular invasion; n.a. = not available; fx = fractions; ER = estrogene receptor; PR = progesterone receptor