Table 1.
AML patients’ characteristics
| AML sample | Gender | Age (yo) | WHO 2008 category | Karyotype | NPM1,FLT3-ITD, CEBPA and DNMT3A mutational status | Chemosensitivity |
|---|---|---|---|---|---|---|
| #1 | M | 28 | AML NOS, without maturation | 46, XY | FLT3 ITD | CS |
| #2 | M | 40 | AML with mutated CEBPA | 46, XY | CEBPAmut | |
| #3 | F | 34 | AML with myelodysplasia-related changes | 45, XX, −7 | FLT3 ITDneg, NPM1wt | CR |
| #4 | M | 45 | AML with t(6,9)(p23;q34);DEK-NUP214 | 46, XY, t(6;9)(p23;q34) | FLT3 ITD | CS |
| #6 | M | 61 | AML with t(8;21)(q22;q22); RUNX1-RUNX1T1 | 45, X–Y, t(8;21)(q22;q22)[19]/46, XY | FLT3 ITDneg, NPM1wt | CS |
| #7 | F | 58 | AML with myelodysplasia-related changes | 46, XX, del(5)(q23q33), t(8;9)(p11;q34) | FLT3 ITDneg, NPM1wt | |
| #8 | M | 24 | AML with myelodysplasia-related changes | 46, XY | FLT3 ITDneg, NPM1wt | |
| #9 | M | 49 | AML with myelodysplasia-related changes | Complex karyotype | FLT3 ITDneg, NPM1wt | |
| #10 | F | 66 | AML with myelodysplasia-related changes | 46, XX, del(11)(q22q23) | FLT3 ITD | |
| #11 | M | 22 | AML with t(8;21)(q22;q22); RUNX1-RUNX1T1 | 45, X, −Y, t(8;21)(q22;q22)/46, XY | FLT3 ITD | CS |
| #12 | F | 22 | AML with inv(16)(p13.1q22);CBFB-MYH11 | 46, XX, inv(16)(p13q22)/46, XX | FLT3 ITDneg, NPM1wt | |
| #13 | M | 37 | AML with mutated NPM1 | 46, XY | NPM1mut, DNMT3Amut | |
| #14 | M | 42 | AML with mutated NPM1 | 46, XY | NPM1mut, FLT3 ITD | |
| #15 | F | 60 | AML with myelodysplasia-related changes | 48, XX, +8, +21 | FLT3 ITDneg, NPM1wt | |
| #16 | F | 62 | AML NOS, with maturation | 46, XX | FLT3 ITDneg, NPM1wt | |
| #17 | F | 60 | AML with myelodysplasia-related changes | Complex karyotype | FLT3 ITDneg, NPM1wt | |
| #18 | F | 55 | AML with inv(16)(p13.1q22);CBFB-MYH11 | 46, XX, inv(16)(p13q22)/46, XX | FLT3 ITDneg, NPM1wt | |
| #19 | M | 63 | AML with myelodysplasia-related changes | 46, XY | FLT3 ITD | CR |
| #20 | M | 61 | AML with mutated NPM1 | 46, XY | NPM1mut, DNMT3Amut | CR |
| #21 | F | 51 | AML NOS, acute monoblastic leukemia | Not available | NPM1mut, FLT3 ITDneg | |
| #22 | F | 36 | AML with mutated NPM1 | 46, XX | NPM1mut, FLT3 ITDneg |
M male, F female, yo years old, FLT3-ITD FLT3 internal tandem duplication, CEBPA mut biallelic CEBPA mutation, FLT3 ITD neg absence of FLT3-ITD, NPM1wt wild-type NPM1, NPM1 mut mutated NPM1, Wt wildtype