Table 3.
Reciprocal inter-relation between age and IgG responses to the different biomarkers
| Antigens | MSP4 | CSP | LSA1 | LSA3 | GLURP | Salsa | MSP1 | PF13 | AMA1 | PmCSP | Saliv | schz07/03 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | Rho | P | P*B | |
| CSP | 0.46 | <10−3 | Y | |||||||||||||||||||||||||||||||||
| LSA1 | 0.24 | 0.02 | NS | 0.49 | <10−3 | Y | ||||||||||||||||||||||||||||||
| LSA3 | 0.34 | <10−2 | NS | 0.43 | <10−3 | Y | 0.16 | 0.1 | NS | |||||||||||||||||||||||||||
| GLURP | 0.34 | <10−2 | NS | 0.42 | <10−3 | Y | 0.32 | <10−2 | NS | 0.33 | <10−2 | NS | ||||||||||||||||||||||||
| Salsa | 0.44 | <10−3 | Y | 0.63 | <10−3 | Y | 0.28 | <10−2 | NS | 0.43 | <10−3 | Y | 0.48 | <10−3 | Y | |||||||||||||||||||||
| MSP1 | 0.37 | <10−3 | Y | 0.25 | 0.01 | Ns | 0.28 | <10−2 | NS | 0.21 | 0.04 | NS | 0.26 | 0.01 | NS | 0.20 | 0.05 | NS | ||||||||||||||||||
| PF13 | 0.44 | <10−3 | Y | 0.39 | <10−3 | Y | 0.21 | 0.04 | NS | 0.39 | <10−3 | Y | 0.33 | <10−2 | NS | 0.54 | <10−3 | Y | 0.06 | 0.51 | NS | |||||||||||||||
| AMA1 | 0.46 | <10−3 | Y | 0.52 | <10−3 | Y | 0.18 | 0.07 | NS | 0.49 | <10−3 | Y | 0.33 | <10−2 | NS | 0.76 | <10−3 | Y | 0.22 | 0.03 | NS | 0.54 | <10−3 | Y | ||||||||||||
| P m CSP | 0.40 | <10−3 | Y | 0.48 | <10−3 | Y | 0.22 | 0.03 | NS | 0.54 | <10−3 | Y | 0.37 | <10−3 | Y | 0.55 | <10−3 | Y | 0.0 | 0.1 | NS | 0.55 | <10−3 | Y | 0.53 | <10−3 | Y | |||||||||
| Saliv | 0.26 | 0.01 | NS | 0.32 | <10−2 | NS | 0.04 | 0.64 | NS | 0.37 | <10−3 | Y | 0.11 | 0.3 | NS | 0.39 | <10−3 | Y | 0.29 | <10−2 | NS | 0.41 | <10−3 | Y | 0.46 | <10−3 | Y | 0.30 | <10−2 | NS | ||||||
| schz07/03 | 0.20 | 0.06 | NS | 0.20 | 0.04 | NS | 0.20 | 0.04 | NS | 0.06 | 0.5 | NS | 0.42 | <10−3 | Y | 0.24 | 0.02 | NS | 0.25 | 0.01 | NS | 0.3 | <10−2 | NS | 0.24 | 0.017 | NS | 0.14 | 0.17 | NS | 0.15 | 0.14 | NS | |||
| Age | 0.21 | 0.04 | NS | 0.36 | <10−2 | NS | 0.18 | 0.07 | NS | 0.15 | 0.14 | NS | 0.50 | <10−3 | Y | 0.32 | <10−2 | NS | 0.0 | 0.1 | NS | 0.3 | <10−2 | NS | 0.20 | 0.05 | NS | 0.29 | 0.005 | NS | 0.03 | 0.73 | NS | 0.30 | <10−2 | NS |
* Probablity of correlation after bonferoni correction for all determinations (n = 78; P < 0.0006), Y significant, NS non significant
In this double entry table are summarized results from reciprocal analysis of correlation between antibody responses to all antigens, and between age and antibody responses on the last line. Strong inter-relation between IgG responses against all antigens was evidenced (55 were significant out of 66, P < 0.05), remaining significant for 30 out of 66 after Bonferroni correction (P < 0.0006). Age correlated with antibody responses for 7/12 antigens remaining significant only for GLURP antigen after Bonferroni correction