Table 1.
Enriched pathways in differentially expressed genes in brain and primary cultures of Fmr1KO mice
| KEGG pathway (ENTREZ ID as input) | p value | No. of genes | Fold enrichment |
|---|---|---|---|
| Hippocampal culture | |||
| mmu04910:Insulin signaling pathway | 0.001 | 35 | 1.748 |
| mmu03040:Spliceosome | 0.001 | 32 | 1.801 |
| mmu00900:Terpenoid backbone biosynthesis | 0.002 | 8 | 3.796 |
| mmu04720:Long-term potentiation | 0.003 | 20 | 2.013 |
| mmu04120:Ubiquitin mediated proteolysis | 0.008 | 32 | 1.586 |
| mmu04360:Axon guidance | 0.009 | 31 | 1.584 |
| mmu03010:Ribosome | 0.011 | 22 | 1.740 |
| mmu05211:Renal cell carcinoma | 0.013 | 19 | 1.803 |
| mmu04540:Gap junction | 0.017 | 21 | 1.701 |
| mmu04722:Neurotrophin signaling pathway | 0.017 | 29 | 1.541 |
| mmu00230:Purine metabolism | 0.022 | 33 | 1.461 |
| mmu00650:Butanoate metabolism | 0.029 | 11 | 2.088 |
| mmu04012:ErbB signaling pathway | 0.031 | 21 | 1.603 |
| mmu05215:Prostate cancer | 0.038 | 21 | 1.567 |
| mmu03018:RNA degradation | 0.039 | 15 | 1.748 |
| mmu03020:RNA polymerase | 0.040 | 9 | 2.214 |
| mmu00790:Folate biosynthesis | 0.070 | 5 | 3.019 |
| mmu04914:Progesterone-mediated oocyte maturation | 0.078 | 19 | 1.485 |
| mmu04150:mTOR signaling pathway | 0.080 | 13 | 1.661 |
| mmu00240:Pyrimidine metabolism | 0.088 | 20 | 1.444 |
| mmu05220:Chronic myeloid leukemia | 0.088 | 17 | 1.506 |
| Cortical culture | |||
| mmu04622:RIG-I-like receptor signaling pathway | 0.001 | 23 | 2.027 |
| mmu03040:Spliceosome | 0.001 | 37 | 1.686 |
| mmu04722:Neurotrophin signaling pathway | 0.006 | 36 | 1.548 |
| mmu04144:Endocytosis | 0.012 | 48 | 1.395 |
| mmu04660:T cell receptor signaling pathway | 0.013 | 31 | 1.529 |
| mmu04010:MAPK signaling pathway | 0.016 | 63 | 1.308 |
| mmu04120:Ubiquitin mediated proteolysis | 0.018 | 36 | 1.444 |
| mmu05220:Chronic myeloid leukemia | 0.029 | 22 | 1.577 |
| mmu04720:Long-term potentiation | 0.052 | 19 | 1.548 |
| mmu00534:Heparan sulfate biosynthesis | 0.062 | 9 | 2.016 |
| mmu03450:Non-homologous end-joining | 0.076 | 6 | 2.481 |
| mmu04062:Chemokine signaling pathway | 0.080 | 41 | 1.267 |
| mmu05210:Colorectal cancer | 0.096 | 22 | 1.391 |
| Hippocampus in situ | |||
| mmu04144:Endocytosis | 0.013 | 14 | 2.133 |
| mmu04060:Cytokine-cytokine receptor interaction | 0.013 | 16 | 1.986 |
| mmu05322:Systemic lupus erythematosus | 0.014 | 8 | 3.088 |
| mmu04514:Cell adhesion molecules (CAMs) | 0.017 | 11 | 2.348 |
| mmu05320:Autoimmune thyroid disease | 0.028 | 6 | 3.451 |
| mmu05330:Allograft rejection | 0.051 | 5 | 3.523 |
| mmu04672:Intestinal immune network for IgA production | 0.082 | 5 | 2.998 |
| mmu04610:Complement and coagulation cascades | 0.099 | 6 | 2.415 |
| Cortex in situ | |||
| mmu00590:Arachidonic acid metabolism | 0.016 | 9 | 2.727 |
| mmu04210:Apoptosis | 0.029 | 9 | 2.439 |
| mmu04640:Hematopoietic cell lineage | 0.059 | 8 | 2.275 |
| mmu04060:Cytokine-cytokine receptor interaction | 0.064 | 16 | 1.623 |
| mmu00601:Glycosphingolipid biosynthesis | 0.083 | 4 | 3.838 |
Italics highlight pathways with p values <0.05