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. 2015 Dec 21;15:290. doi: 10.1186/s12862-015-0561-4

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© Pedroso et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Electrostatic surface charge distribution of Class I and II SMases D highlighting the catalytic interface. The ellipses indicate the active-site pocket. a Class I; b Class II