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. Author manuscript; available in PMC: 2016 Apr 30.
Published in final edited form as: Science. 2015 Oct 15;350(6260):aab4070. doi: 10.1126/science.aab4070

Fig. 1. Cryo-EM reconstructions of Tetrahymena telomerase holoenzyme.

Fig. 1

(A) Front view of the 9.4 Å cryo-EM map, with the catalytic core, Teb1C-Teb2N-Teb3 (TEB), p75C-p45N-p19 (CST), and p50N colored in blue, gold, copper, and red, respectively. (B) Front view of the 9.4 Å cryo-EM map (gray surface) with pseudoatomic models of the TERT-TER-p65 catalytic core, Teb1C-Teb2N-Teb3, and p75C-p45N-p19. (C) Side view of the cryo-EM map and pseudoatomic models shown in (B). (D) Back view of the 8.9 Å cryo-EM map colored as in (A). (E) Back view of the 8.9 Å cryo-EM map, showing pseudoatomic models of TERT-TER-p65 and Teb1C-Teb2N-Teb3. (F) Close-up views of fitting of TER helical domains PK, SL2, S1, and SL4 and TEN domain into the 8.9 Å cryo-EM map. TERT domains are TEN (cyan), TRBD (dark blue), RT (violet, with IFD labeled in violet), and CTE (light blue). Other proteins and TER are colored individually.