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. Author manuscript; available in PMC: 2016 Apr 30.
Published in final edited form as: Science. 2015 Oct 15;350(6260):aab4070. doi: 10.1126/science.aab4070

Fig. 2. Structure of the TERT-TER-p65 catalytic core.

Fig. 2

(A) Model structure of TERT, showing the putative IFD (light violet), active-site catalytic triad residues (red), linker (dotted blue line), and TER TRE. (B) Secondary structure of TER. Locations of CTE and TRBD on TER are indicated with dotted lines. (C) Pseudoatomic model of TERT ring-TER, showing TBE-template-TRE and L4 on TERT, viewed from the active-site side of TERT. (D) Front view of the 8.9 Å cryo-EM map, showing a pseudoatomic model of TER. (E) Front view of the pseudoatomic model TERT-TER-p65 catalytic core. The putative location of IFD is shown as violet oval. (F) A region of the 8.9 Å cryo-EM map and pseudoatomic model showing L4 at the interface of TRBD (helix α8) and CTE (helix α22a, residues 975 to 983). The numbering of Tetrahymena TERT secondary structure elements follows that of the Tribolium TERT structure.