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. Author manuscript; available in PMC: 2016 Apr 30.
Published in final edited form as: Science. 2015 Oct 15;350(6260):aab4070. doi: 10.1126/science.aab4070

Fig. 7. Schematics of the complete Tetrahymena telomerase holoenzyme and DNA exit path.

Fig. 7

(A) Arrangement of the subunits and domains of the Tetrahymena telomerase catalytic core, TEB, and CST complexes tethered to p50, shown as front view. Domains connected by flexible linkers and not seen in the cryo-EM map are shown with oval outlines. (B) Arrangement of the holoenzyme with proposed path of telomere ssDNA, shown as back view. Teb1AB domains are presumed to be ordered when DNA-bound.