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. 2015 Mar 23;29(10):2101–2104. doi: 10.1038/leu.2015.67

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Persistence of DNMT3A mutations in complete remission. The allelic burden of DNMT3A (R882H/C) mutation was measured using a custom Sequenom assay in serial samples from a cohort of 12 additional patients with DNMT3A-mutant AML, those in whom the mutation was detected during complete remission are shown. Active AML (black), remission (red). Sample types—Dx (diagnosis), CR1 (first complete remission), CR2 (second complete remission), Rel (relapse), P1 (first sample post-BMT), P2 (second sample post-BMT). Numbers along x-axis are time after diagnosis (months).