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A clot was induced in the M1 segment of the right middle cerebral artery by injecting thrombin through an endovascular microcatheter introduced through the femoral artery in a fresh human cadaver, and flow in the arteries was maintained by a saline pumping system. MRgFUS targeted the right M1 clot (arrows) and with a total of 4 sonications, the clot was completely sonothrombolyzed over 10 minutes.
