Figure 2.

Model showing potential intervention points and hypothesised decline of beta‐cells as currently seen in type 1 diabetes (T1D) 16. Four key therapeutic windows of opportunity exist in the natural history of T1D – :primary prevention (prior to formation of any T1D‐associated autoantibodies); secondary prevention (post‐autoantibody development); secondary prevention with dysglycaemia (post‐autoantibody development with abnormal glucose tolerance); and finally T1D intervention/preservation (post‐hyperglycaemic onset).