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. 2015 Oct 12;183(1):129–142. doi: 10.1111/cei.12693

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© 2015 British Society for Immunology

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Changes in the differentiation of inducible co‐stimulatory (ICOS)⁺ and ICOS⁻ regulatory T cells (T_regs) during the normal pregnancy course and in the presence of pre‐eclampsia and haemolysis elevated liver enzymes low platelet (HELLP) syndrome. The percentages of CD45RA⁺CD31⁺ recent thymic emigrant (RTE) T_regs (a,e), CD45RA⁺CD31⁻mature naive (MN) T_regs (b,f), CD45RA⁻CD31⁺ memory T_regs (c,g) and CD45RA⁻CD31⁻ memory T_regs (d,h) within the ICOS⁺ and ICOS⁻ T_reg pool were estimated in healthy non‐pregnant fertile women (group 1, ), healthy pregnant women during their pregnancy course (groups 2–5, ◆), spontaneously term labouring women (group 6, ), 1 day postpartum (group 7, ◆) and in women with pre‐eclampsia (group 8, ) or HELLP syndrome (group 9, ). Significant differences concerning the percentages of the different T_reg subsets were detected between women during the normal pregnancy course (groups 2–5) and non‐pregnant women (group 1) or women with spontaneous term labour (group 6). Significant differences were also observed between spontaneously term labouring women (group 6) and women 1 day postpartum (group 7). In addition, significant differences were detected between healthy third‐trimester women (groups 4 and 5) and women with pre‐eclampsia (group 8) or HELLP syndrome (group 9).

Inline graphic — Changes in the differentiation of inducible co‐stimulatory (ICOS)⁺ and ICOS⁻ regulatory T cells (T_regs) during the normal pregnancy course and in the presence of pre‐eclampsia and haemolysis elevated liver enzymes low platelet (HELLP) syndrome. The percentages of CD45RA⁺CD31⁺ recent thymic emigrant (RTE) T_regs (a,e), CD45RA⁺CD31⁻mature naive (MN) T_regs (b,f), CD45RA⁻CD31⁺ memory T_regs (c,g) and CD45RA⁻CD31⁻ memory T_regs (d,h) within the ICOS⁺ and ICOS⁻ T_reg pool were estimated in healthy non‐pregnant fertile women (group 1, ), healthy pregnant women during their pregnancy course (groups 2–5, ◆), spontaneously term labouring women (group 6, ), 1 day postpartum (group 7, ◆) and in women with pre‐eclampsia (group 8, ) or HELLP syndrome (group 9, ). Significant differences concerning the percentages of the different T_reg subsets were detected between women during the normal pregnancy course (groups 2–5) and non‐pregnant women (group 1) or women with spontaneous term labour (group 6). Significant differences were also observed between spontaneously term labouring women (group 6) and women 1 day postpartum (group 7). In addition, significant differences were detected between healthy third‐trimester women (groups 4 and 5) and women with pre‐eclampsia (group 8) or HELLP syndrome (group 9).