Table 1.

Interleukin (IL)‐21 production at the site of the autoimmune attack in mouse models of type 1 diabetes. Table shows data relating to IL‐21 expression in mouse models of diabetes.

Publication	Findings	Mouse model
Clough et al. 77	Increased IL‐21 mRNA in pancreatic lymph nodes of diabetic compared with non‐diabetic mice	DO11 × rip‐OVA
Sutherland et al. 78	Increased IL‐21 mRNA were in the pancreas of diabetic compared with non‐diabetic mice	NOD
McGuire et al. 84	Enrichment of IL‐21‐producing T cells within the pancreas compared with peripheral lymphoid organs. Fewer IL‐21+ T cells were observed in the pancreas of NOD mice bearing the B6 Idd3 region	NOD
Kenefeck et al. 106	Enrichment of IL‐21‐producing T cells within the pancreas compared with peripheral lymphoid organs. The IL‐21‐producing T cells co‐express TNF‐α and IFN‐γ but not IL‐17	DO11 × rip‐OVA

NOD = non‐obese diabetic; OVA = ovalbumin; IFN = interferon; TNF = tumour necrosis factor.