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. 2015 Dec 1;112(50):15420–15425. doi: 10.1073/pnas.1516362112

Fig. S10.

Fig. S10.

PERK inhibitor elicits pancreatic toxicity in an IFNAR1-dependent manner. GSK2606414-treated wild-type mice are more glucose intolerant and secrete less stimulated insulin compared with the same treated Ifnar1−/− mice. (A) Glucose tolerance test of vehicle or GSK2606414-treated wild-type or Ifnar1−/−mice (n = 5 for each). #P < 0.05; ##P < 0.01 compared to R1−/−-PERKi. Areas under curve were quantified in B. Blood was also sampled for secreted insulin at 0 and 15 min after glucose delivery during glucose tolerance test (C). *P < 0.05; **P < 0.01; ***P < 0.001.