Fig. 5.

Proposed model for how IL12RB1 RDDs regulate IL12/IL23 responsiveness. Before PBMC stimulation, the IL12RB1 gene is transcribed into RDD-containing (RDD^POS) mRNAs that are translated into IL12Rβ1 proteins with diminished IL12p40-binding capacity; as a consequence, unstimulated PBMCs are less responsive to IL12/IL23 (only IL12 is depicted). After PBMC stimulation, the introduction of RDDs into IL12RB1 mRNAs declines, producing IL12RB1 mRNAs that lack RDDs (RDD^NEG) and allowing for translation of IL12Rβ1 proteins that confer IL12/IL23-responsiveness.