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. 2015 Nov 30;112(50):15414–15419. doi: 10.1073/pnas.1515978112

Fig. S2.

Fig. S2.

RDD exon enrichment in IL12RB1 mRNA clones before and after activation with PHA. Shown for each PBMC donor is the extent to which RDDs are exon-enriched in their IL12RB1 mRNA clones, both before and after activation with PHA. The length of each IL12RB1 mRNA was divided into 17 portions based on exon boundaries (horizontal axis), and the “RDD rate” for each portion is plotted for each individual (vertical axis). Each PBMC donor is represented by a different line color; the left half of the figure shows the RDD rates in each mRNA portion before PBMC activation (PHA−), whereas the right half of the figure shows the RDD rates in each mRNA portion after PBMC activation (PHA+). Listed adjacent to the figure legend is the IFNγ level in the supernatant of each PBMC preparation after its activation with PHA. The average RDD rate for each IL12RB1 mRNA portion across all donors was used to generate the graph shown in Fig. 4B.