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. 2015 Dec 15;9:6445–6460. doi: 10.2147/DDDT.S93481

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© 2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The apoptosis and necrosis of GLC-82 cells analyzed by flow cytometry after different treatments.

Notes: (A) Negative control group; (B) free C225 group (C225 solution); (C) gene therapy group (gene-loaded albumin nanospheres, IFNG-ANS); (D) C225-targeted gene therapy group (C225-IFNG-IANS); (E) MFH group (MANS); (F) C225-targeted MFH (C225-IMANS) group; (G) gene therapy and MFH combination group (IFNG-MANS); (H) C225-targeted gene therapy and MFH combination group (C225-IFNG-IMANS).

Abbreviations: ANS, albumin nanospheres; PI, propidium iodide; MANS, magnetic albumin nanospheres; IMANS, immunomagnetic albumin nanospheres; MFH, magnetic fluid hyperthermia; C225, cetuximab; FITC, fluorescein isothiocyanate; IANS, albumin immuno-nanospheres.