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. 2015 Dec 15;10(12):e0145086. doi: 10.1371/journal.pone.0145086

Table 2. Annualized healthcare utilization before and after diagnosis, by study group.

Before diagnosis After diagnosis
Brucellosis cases (n = 467) Control group A (n = 1404) Brucellosis cases (n = 467) Control group A (n = 1404)
Total Cost Costs (2013USD) 439 ± 1592 (52, 6–260) 382 ± 1495 (36, 3–209)* 1327 ± 2347 (320, 142–1349) ## 380 ± 1472 (40, 2–231)**
Hospitalization Costs (2013USD) 141± 893 (0,0–0) 108 ± 716 (0,0–0) 892 ± 2053 (0, 0–636) ## 113 ± 799 (0, 0–0) **
Number of hospitalization 0.10 ± 0.54 (0, 0–0) 0.08 ± 0.45 (0, 0–0) 0.52 ± 1.17 (0, 0–1) ## 0.08 ± 0.54 (0, 0–0) **
Number of days 0.23 ± 1.44 (0, 0–0) 0.20 ± 1.28 (0, 0–0) 1.67 ± 3.79 (0, 0–1) ## 0.20 ± 1.41 (0, 0–0) **
% Hospitalized 6.0 5.0 27.6 5.0 ʃ
Length of stay 3.89 ± 4.59 (2, 1–5) 3.91 ± 4.33 (3, 2–4) 6.03 ± 5.08 (4, 3–7) 4.09 ± 4.91 (3, 1–5) **
Long-term hospitalization Costs (2013USD) 11 ± 236 (0, 0–0) 4 ± 152 (0, 0–0) 12 ± 262 (0, 0–0) 3 ± 114 (0, 0–0)
Number of hospitalization 0.01 ± 0.19 (0, 0–0) 0.00 ± 0.08 (0, 0–0) 0.01 ± 0.19 (0, 0–0) 0.00 ± 0.05 (0, 0–0)
Number of days 0.06 ± 1.34 (0, 0–0) 0.02 ± 0.83 (0, 0–0) 0.07 ± 1.43 (0, 0–0) 0.02 ± 0.64 (0, 0–0)
Diagnostic procedures Costs (2013USD) 43 ± 114 (0, 0–34) 44 ± 143 (0, 0–22) 62 ± 158 (0, 0–50) ## 46 ± 145 (0, 0–26)**
Number of procedures 1.12 ± 2.17 (0, 0–2) 0.97 ± 2.12 (0, 0–1)* 1.41 ± 2.13 (0, 0–2) ## 0.96 ± 1.96 (0, 0–1) **
Medications Costs (2013USD) 58 ± 436 (11, 2–30) 63 ± 410 (8, 0–27) 108 ± 540 (44, 27–70) ## 59 ± 310 (8, 0–30) **
Number of Rx 9.36 ± 14.15 (4, 1–12) 9.95 ± 18.39 (3, 1–10) * 14.54 ± 15.35 (10, 6–17) ## 10.12 ± 18.93 (3, 0–10) **
Surgical procedures Costs (2013USD) 86 ± 727 (0, 0–0) 73 ± 824 (0, 0–0) 30 ± 360 (0, 0–0) 59 ± 641 (0, 0–0)
Number of surgeries 0.02 ± 0.15 (0, 0–0) 0.01 ± 0.12 (0, 0–0) 0.01 ± 0.10 (0, 0–0) 0.02 ± 0.16 (0, 0–0)
Specialist visits Costs (2013USD) 31 ± 65 (0, 0–35) 29 ± 66 (0, 0–31) 37 ± 65 (0, 0–49) # 30 ± 65 (0, 0–30) *
Number of visits 1.37 ± 2.69 (0, 0–2) 1.28 ± 2.73 (0, 0–2) 1.58 ± 2.66 (0, 0–2) # 1.33 ± 2.84 (0, 0–2) *
Emergency Room visits Costs (2013USD) 46 ± 103 (0, 0–0) 34 ± 98 (0, 0–0)* 118 ± 175 (0, 0–179) ## 42 ± 105 (0, 0–0) **
Number of visits 0.26 ± 0.58 (0, 0–0) 0.19 ± 0.55 (0, 0–0) * 0.67 ± 0.99 (0, 0–1) ## 0.23 ± 0.58 (0, 0–0) **
Outpatient visits Costs (2013USD) 9 ± 84 (0, 0–0) 10 ± 187 (0, 0–0) 11 ± 133 (0, 0–0) 12 ± 198 (0, 0–0)
Number of visits 0.03 ± 0.27 (0, 0–0) 0.03 ± 0.52 (0, 0–0) 0.03 ± 0.46 (0, 0–0) 0.03 ± 0.51 (0, 0–0)
Laboratory tests Costs (2013USD) 14 ± 32 (1, 0–18) 16 ± 78 (0, 0–14) * 58 ± 56 (46, 27–74) ## 16 ± 112 (0, 0–13) **
Number of tests 8.54 ± 12.90 (1, 0–15) 7.34 ± 13.11 (0, 0–14) * 21.40 ± 19.35 (17, 6–31) ## 7.94 ± 14.99 (0, 0–14) **

Values are mean ±SD (median, 25 percentile-75 percentile).

* Mann-Whitney U test, P<0.05;

** P<0.001.

# Wilcoxon matched-pairs signed-ranks test, P<0.05;

## <0.001.

ʃ Chi-squared test, P<0.001.