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. 2015 Aug 20;19(12):2715–2727. doi: 10.1111/jcmm.12657

Figure 7.

Figure 7

Nlrp3 deficiency inhibits high‐fat diet (HFD)‐induced increases of high mobility group box protein 1 (HMGB1) release in coronary arterial endothelium. Wild‐type (Nlrp3+/+) or Nlrp3 knockout (Nlrp3−/−) Mice were fed with normal diet (ND) and high‐fat diet (HFD) for 6 weeks. Frozen sections of mouse hearts were used for confocal immunofluorescent analysis. (A) Representative confocal fluorescence images of HMGB1 with endothelium marker vWF in coronary arteries of mice. Enlarged images of area of interest (AOI) in merged images are shown; scale bar = 50 μm. (B) The summarized data show the colocalization coefficient (PCC) of HMGB1 with vWF (n = 4–8). *P < 0.05 versus Nlrp3 +/+ with ND; # P < 0.05 versus Nlrp3 +/+ with HFD.