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. 2015 Sep 23;19(12):2832–2841. doi: 10.1111/jcmm.12675

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The effect of overexpression of Dickkopf‐related protein 3 (DKK3) on tumour growth in vivo. (A) Measurements of tumour volume at various time‐points revealing in vivo therapeutic efficacy of gemcitabine. DKK3 significantly decreased the mean tumour volume compared to normal control and blank group animals (*P < 0.05; n = 6). Points, mean; bars, S.E. Immunohistochemical analysis of β‐catenin (B–D), E‐cadherin (E–G) and CD133 (H–J) protein expression in pancreatic subcutaneous tumour samples from blank, NC and DKK3 group, respectively, scale bar: 50 μm.