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. 2015 Oct 16;19(12):2751–2762. doi: 10.1111/jcmm.12703

Figure 5.

Figure 5

Functional mast cell (MC) implantation is associated with augmentation of the inflammatory response. Infiltration of neutrophils into the (A) infarct region was increased at day 3 post infarction for the MC‐implanted group and at day 7 for both the MC‐ and bone marrow (BM) cell‐implanted groups while (B) no differences were seen in the non‐infarct regions with or without cell transplantation, evaluated by flow cytometry (n = 3, **P < 0.01 versus medium alone). Infiltration of macrophages into the (C) infarct region was increased in cell‐implanted mice at both time‐points while the (D) non‐infarct region saw no increase, evaluated by flow cytometry against F4/80 (n = 3, **P < 0.01 versus medium alone). TNF‐α concentration in the (E) infarct increases by 3 days after MC implantation and by 7 days after BM cell implantation while (F) no such increase was seen in the non‐infarcted regions, assessed by ELISA (n = 6, **P < 0.01 versus medium alone).