Skip to main content
. 2015 Oct 16;19(12):2751–2762. doi: 10.1111/jcmm.12703

Figure 7.

Figure 7

Enhanced angiogenesis is the predominant contributor to improved cardiac function after cell implantation. (A) Capillary density in the border zone was increased at day 3, 7 and 28 after wild‐type mast cell (MC) or bone marrow (BM) cell implantation, quantified by isolectin staining (n = 5/group,*P < 0.05 and **P < 0.01 versus medium‐injected control, scale bar = 100 μm). (B) Whole heart serial sections at day 7 and 28 post‐cell implantation illustrate ventricular dilation in MC and medium injected controls at the later time‐point. Infarct scar area was quantified as a percentage of left ventricular (LV) area (n = 6/group, **P < 0.01 versus medium‐injected control). (C) α‐SMA staining for myofibroblast accumulation in the border zone post implantation shows increased myofibroblast accumulation in the MC injected hearts 7 days post transplantation compared to their BM‐injected counterparts. Quantification of the α‐SMA + area excluded blood vessel structures (n = 5/group, **P < 0.01 versus medium‐injected control, scale bar = 100 μm).