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. Author manuscript; available in PMC: 2015 Dec 22.
Published in final edited form as: Biochem Biophys Res Commun. 2014 Jan 16;444(1):56–62. doi: 10.1016/j.bbrc.2014.01.003

Figure 1. Thyroid hormone status regulates expression of secretory PLA2 in BALB/c and C57BL/6 hPLA2 IIA+ mice.

Figure 1

BALB/c mice were made hypothyroid or hyperthyroid as described in the materials and methods. Mice were sacrificed and liver RNA was harvested. The mRNA levels were measured for A) PLA2g2a, B) PDK4, C) PEPCK and D) CPT1a. Values are the average of RNA from 5 mice. C57BL/6 IIA+ mice were fed a PTU supplemented diet for 5 weeks. Mice were injected with T3 and RNA was harvested from the liver. The mRNA levels were measured for E) PLA2g2a, F) PLA2g1b, G) PLA2g3, H) PLA2g5, I) PEPCK, J) PDK4 and K) SREBP-1c. L) PLA2g2a protein abundance was measured by western blotting. Values are the average of RNA from 7 mice. The data are expressed as the mean of the fold induction by PTU+T3 ± S.E.M of mRNA abundance relative to PTU treated mice (* = p value < 0.05; ** = p value <0.01; *** = p value <0.001; ****= p value <0.0001).